NAPLEX Questions: Clinical Patient Profile Practice Questions

Feb 5

The NAPLEX exam is heavy on clinical pharmacy topics, and you will get questions in the form of a patient profile. This blog article provides you with a few clinical and patient profile NAPLEX questions to help you practice. Scroll to the end to see the answers and explanations.

Content accurate at the time of publishing: 2/5/2023

NAPLEX Practice question 1

Question: What type of drugs are primarily metabolized by CYP3A4 enzyme?

A) Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

B) Tricyclic Antidepressants (TCAs)

C) Calcium Channel Blockers (CCBs)

D) Statins

E) Benzodiazepines

NAPLEX Practice question 2

Question: A 50-year-old female patient is taking oral contraceptives and presents with complaints of headaches and visual changes. What medication class should be avoided in this patient's treatment plan?

A) Nonsteroidal anti-inflammatory drugs (NSAIDs)

B) Acetaminophen

C) Triptans

D) Opioid pain relievers

NAPLEX Practice question 3

Patient Profile: A 50-year-old male presents to the clinic with complaints of chest pain and shortness of breath. He has a history of hypertension and hyperlipidemia.

Question: What is the most appropriate initial pharmacological management for this patient's chest pain and shortness of breath?

A. Nitroglycerin

B. Metoprolol

C. Aspirin

D. Clopidogrel

NAPLEX Practice question 4

Patient Profile: A 65-year-old female with a history of type 2 diabetes presents with proteinuria and a creatinine level of 1.8 mg/dL.

Question: What is the most appropriate initial management for this patient's proteinuria?

A. ACE inhibitors

B. ARBs

C. Thiazide diuretics

D. Calcium channel blockers

NAPLEX Practice question 5

A 55-year-old female patient presents with hypertension and osteoarthritis. She is currently taking amlodipine and celecoxib. She reports experiencing occasional stomach discomfort and requests a medication to alleviate it. As the pharmacist, what would be your recommendations for addressing this patient's symptom while ensuring safe medication use?

A) Recommend switching her to a different class of antihypertensive medication, such as an ACE inhibitor or ARB, as they have been shown to have gastrointestinal side effects.

B) Add a proton pump inhibitor (PPI) to her current regimen, as it can decrease the risk of stomach ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs) like celecoxib.

C) Switch her celecoxib to ibuprofen, as it has a lower risk of causing stomach discomfort.

D) Recommend a histamine H2 receptor antagonist (H2RA) in addition to her current regimen, as it can decrease the risk of stomach ulcers caused by NSAIDs.

NAPLEX Practice question 6

A 35-year-old female patient presents with symptoms of gastroesophageal reflux disease (GERD) such as heartburn and regurgitation. She reports taking over-the-counter antacids with limited relief and would like to try a prescription medication. As the pharmacist, which medication would you recommend for her?

A) Esomeprazole

B) Famotidine

C) Rabeprazole

D) Omeprazole

NAPLEX Practice question 7

A 6-years-old child presents with sever ear pain. Diagnosis was confirmed as acute otitis media (AOM). Patient weight is 20 kg

Allergies: NKDA.

The pediatrician decides to prescribe antibiotics after a week of wait-and-see approach.

What is the first line treatment?

A. Amoxicillin-clavulanate

B. Cefdinir

C. Azithromycin

D. Ceftriaxone

Scroll down to see the answers and explanation to the presented NAPLEX Practice Questions.

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NAPLEX practice

Answers to the NAPLEX clinical questions presented above

NAPLEX Practice question 1 - Answer: D) Statins

CYP3A4 is a hepatic cytochrome P450 enzyme that is primarily responsible for the metabolism of a number of drugs, including statins, which are used to lower cholesterol levels. Some statins, such as simvastatin and atorvastatin, are primarily metabolized by CYP3A4. Other drugs, such as benzodiazepines (E), are also metabolized by CYP3A4, but statins are the type of drugs primarily metabolized by this enzyme.

NAPLEX Practice question 2 -Answer: C) Triptans

Triptans should be avoided in patients who are taking oral contraceptives, as the combination can increase the risk of serious side effects such as cerebral vasoconstriction and stroke. This is particularly true for women who smoke or have a history of migraine headaches. In this patient profile, it would be best to avoid Triptans and instead consider alternative pain relief options such as Nonsteroidal anti-inflammatory drugs (NSAIDs), Acetaminophen, Opioid pain relievers, or Aspirin. It is important to carefully consider the patient's overall health profile and potential drug interactions before choosing a medication for the treatment of headaches and other types of pain.

NAPLEX Practice question 3 - Answer: A) Nitroglycerin

NAPLEX Practice question 4 - Answer: A) ACE inhibitors

ACE inhibitors are first-line drugs for the treatment of proteinuria in patients with diabetic nephropathy. They help reduce proteinuria and slow the progression of renal disease. Additionally, ACE inhibitors have a blood pressure-lowering effect, which is also beneficial for patients with diabetes.

NAPLEX Practice question 5 - Answer: B

Adding a PPI to her current regimen can decrease the risk of stomach ulcers caused by celecoxib, a NSAID which is known to have gastrointestinal side effects. This would be the most appropriate and effective approach to ensuring safe medication use while addressing the patient's symptom.

NAPLEX Practice question 6 - Answer: A) Esomeprazole

Esomeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach and is considered first-line therapy for the treatment of GERD. It is more effective than H2-receptor antagonists (such as Famotidine) and has been shown to have a higher healing rate and longer duration of action compared to other PPIs like omeprazole, lansoprazole, and rabeprazole.

NAPLEX Practice question 7 - Answer: A) Amoxicillin-clavulanate

Amoxicillin-clavulanate is the most commonly prescribed first-line antibiotic for children with acute otitis media. It is effective against S. pneumoniae and H. influenzae, the most common causative organisms. If the child has a penicillin allergy, alternative antibiotics such as cefuroxime or azithromycin may be used. In some cases, particularly when the symptoms are mild, a wait-and-see approach may be appropriate, as many cases of AOM will resolve on their own without antibiotics. Pain relief, such as acetaminophen or ibuprofen, may be recommended to help manage symptoms.

Other options like cefdinir (B) and azithromycin (C) are also effective but are used less frequently due to concerns about increasing bacterial resistance. Ceftriaxone (D) is typically reserved for severe or complicated cases as it is given by injection.

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